Doxpicomine in postoperative pain

In a single‐dose study the analgesic activity of 400 mg doxpicomine was compared with 4 and 8 mg morphine administered intramuscularly. Our subjects were 43 men with moderate or severe postsurgical pain on the first postoperative day. Results of a double‐blind trial indicate the analgesic activity of 400 mg intramuscular doxpicomine to be within the range of 8 mg morphine. There was no statistical significance between the effects of 400 mg doxpicomine and 8 mg morphine with the exception of half‐hour data where doxpicomine was more effective than morphine. Doxpicomine has a rapid onset of analgesic action, the duration of which is equivalent to that of 8 mg morphine. Clinical Pharmacology and Therapeutics (1981) 29 , 771–775; doi: 10.1038/clpt.1981.109