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Ticrynafen in anephric patients: Effects on uric acid and pharmacokinetics
Author(s) -
Murray Thomas G,
Brown Steven,
Dubb Jeffrey W,
Hwang Bruce Y,
Stote Robert M
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.97
Subject(s) - hemodialysis , uric acid , metabolite , pharmacokinetics , clinical pharmacology , medicine , endocrinology , serum concentration , pharmacology , serum cholesterol , cholesterol
Ticrynafen was given to 6 anephric patients undergoing maintenance hemodialysis. Ticrynafen was given daily for the 3 days between hemodialyses. Ticrynafen had no effect on the interdialysis rise in serum uric acid levels. Ticrynafen did not accumulate in serum, but levels of metabolites continued to rise over the 3 days. Hemodialysis (5 hr) reduced levels of ticrynafen by 38% but had less effect on metabolite levels. There was no effect on serum cholesterol or triglycerides. Clinical Pharmacology and Therapeutics (1980) 27, 686–689; doi: 10.1038/clpt.1980.97