Effect of acute methadone withdrawal on prostaglandin E‐stimulated  3 H‐cyclic adenosine monophosphate accumulation in human platelets | Zendy

Pandey Ghanshyam N | Zendy; DeLeonJones Frank A | Zendy; Inwang Edet E | Zendy; Davis John M | Zendy

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Effect of acute methadone withdrawal on prostaglandin E‐stimulated 3 H‐cyclic adenosine monophosphate accumulation in human platelets

Author(s) -

Pandey Ghanshyam N,

DeLeonJones Frank A,

Inwang Edet E,

Davis John M

Publication year - 1980

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1038/clpt.1980.86

Subject(s) - adenylate kinase , cyclase , platelet , methadone , adenosine , prostaglandin e1 , endocrinology , addiction , cyclic adenosine monophosphate , medicine , chemistry , pharmacology , heroin , prostaglandin e , adenosine monophosphate , drug , receptor , psychiatry

The effect of acute methadone withdrawal was studied on PGE 1 ‐sensitive platelet adenylate cyclase of 8 former heroin addicts who had been stabilized with methadone. During acute methadone withdrawal there was a significant increase in PGE 1 ‐sensitive platelet adenylate cyclase activity, which correlated with the severity of withdrawal symptoms. This suggests that PGE 1 ‐sensitive adenylate cyclase and cyclic adenosine monophosphate (cyclic AMP) are involved in the human addictive process. Clinical Pharmacology and Therapeutics (1980) 27, 607–611; doi: 10.1038/clpt.1980.86

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