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Intravenous azlocillin kinetics in patients on long‐term hemodialysis
Author(s) -
Aletta John M,
Francke Elliot F,
Neu Harold C
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.80
Subject(s) - azlocillin , hemodialysis , dialysis , medicine , half life , penicillin , pharmacokinetics , clearance , chemistry , urology , antibiotics , biochemistry , genetics , bacteria , pseudomonas aeruginosa , biology , piperacillin
The kinetics of the antipseudomonas penicillin, azlocillin, was studied after intravenous injection in 9 patients with creatinine clearance under 7 ml/min. All were on long‐term hemodialysis; 3 were also studied during a dialysis‐free period. Kinetic parameters were derived using a 2‐compartment open model. The mean serum azlocillin half‐life (t½) was 1.93 hr in patients on dialysis and approximately 5 hr off dialysis. Thirty percent of the dose was recovered in the dialysate during a 4‐hr period. An approach to the use of azlocillin in patients undergoing dialysis is presented. Clinical Pharmacology and Therapeutics (1980) 27, 563–566; doi: 10.1038/clpt.1980.80