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Deficient metabolism of debrisoquine and sparteine
Author(s) -
Inaba T,
Otton S V,
Kalow W
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.77
Subject(s) - debrisoquine , sparteine , hydroxylation , metabolite , metabolism , drug metabolism , pharmacogenetics , chemistry , pharmacology , cytochrome p450 , cyp2d6 , biochemistry , biology , stereochemistry , gene , enzyme , genotype
Genetic deficiencies of alicyclic hydroxylation of debrisoquine and of sparteine oxidation are independently discovered entities, each of clinical significance in its sphere. This paper reports evidence to indicate that these 2 deficiencies have the same cause. Previous investigation of one of the affected subjects had revealed normal oxidative metabolism of amobarbital and antipyrine in terms of both metabolic rates and urinary metabolite patterns. Thus the genetic defect in the metabolism of sparteine and debrisoquine is not a generalized deficiency of drug oxidation or of the cytochrome P450 system. Clinical Pharmacology and Therapeutics (1980) 27, 547–549; doi: 10.1038/clpt.1980.77