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Nefopam and propoxyphene in episiotomy pain
Author(s) -
Bloomfield Saul S,
Barden Tom P,
Mitchell Jeanette
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.70
Subject(s) - propoxyphene , placebo , analgesic , medicine , anesthesia , episiotomy , pregnancy , alternative medicine , pathology , biology , genetics
To evaluate relative efficacy, safety, and time course of analgesia, nefopam (45 and 90 mg), a new centrally acting nonnarcotic analgesic, was compared with propoxyphene (65 mg) and placebo in a single oral dose, parallel, stratified, randomized, double‐blind trial with 100 hospitalized postpartum women with medium or severe episiotomy pain. Using subjective reports as indices of response, patients rated pain intensity and side effects at periodic interviews for 6 hr. After 45 and 90 mg nefopam, 21 of 25 and 20 of 25 patients (p < 0.01) reported more than 50% reduction of pain, whereas after 65 mg propoxyphene 18 of 25 (p < 0.05) and after placebo 11 of 25 reported reduction in pain. Relative efficacy, based on summed pain intensity differences, showed measurable but modest dose‐dependent analgesia with nefopam, suggesting that the effectiveness of 65 mg propoxyphene lay between 45 mg nefopam and placebo. Side effects included mild dizziness and hypothermia after nefopam and mild elevation of diastolic arterial pressure after nefopam and propoxyphene. Our results suggest that 45‐ and 90‐mg doses of nefopam induced more analgesia than 65 mg propoxyphene in the relief of episiotomy pain. Clinical Pharmacology and Therapeutics (1980) 27, 502–507; doi: 10.1038/clpt.1980.70