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Relative selective action of propranolol on cardiovascular and respiratory responses to isoproterenol
Author(s) -
Zwillich C W,
Martin B J,
Rose C E
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.63
Subject(s) - blockade , propranolol , heart rate , medicine , respiration , respiratory minute volume , blood pressure , respiratory system , ventilation (architecture) , anesthesia , pharmacology , receptor , mechanical engineering , engineering , anatomy
Organ selectivity of beta sympathetic blockade with propranolol was studied in 6 normal men by comparing the cardiovascular and respiration responses during isoproterenol infusions before and after propranolol. Beta sympathetic blockade was achieved with propranolol and was considered present when there was no heart rate (HR) response to isoproterenol during an infusion tenfold greater than that which raised HR 25% during a control period. During blockade there was no change in HR or systolic or diastolic blood pressure during isoproterenol infusions. There was a consistent (p < 0.05) rise in resting ventilation (+17%), oxygen consumption (+9%), and carbon dioxide production (+15%) with low‐dose (raised HR 10% before blockade) isoproterenol infusion during blockade. These respiratory effects of low‐dose isoproterenol during cardiovascular blockade were quantitatively similar to that before blockade. With infusion that raised HR 25%, there was a further increase in V̇ E , V̇O 2 , and V̇CO 2 before blockade but no further increase during beta blockade. Changes in acid‐base status did not explain the increase in V̇ E during blockade. We conclude that there are differences between effectiveness of propranolol blockade of the cardiovascular system and of the respiratory system. Clinical Pharmacology and Therapeutics (1980) 27, 454–459; doi: 10.1038/clpt.1980.63