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Kinetic evaluation of the propranolol‐quinidine combination
Author(s) -
Fenster Paul,
Perrier Donald,
Mayersohn Michael,
Marcus Frank I
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.62
Subject(s) - quinidine , propranolol , pharmacology , plasma concentration , chemistry , drug , therapeutic index , drug interaction , steady state (chemistry) , kinetics , medicine , endocrinology , physics , quantum mechanics
The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady‐slate plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drug. This study shows no kinetic interaction between quinidine and propranolol in normal subjects. Clinical Pharmacology and Therapeutics (1980) 27, 450–453; doi: 10.1038/clpt.1980.62