Premium
Metabolie disposition of methyldopa in hypertensive and renal‐insufficient children
Author(s) -
O'Dea Robert F,
Mirkin Bernard L
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.6
Subject(s) - methyldopa , impaired renal function , renal function , creatinine , medicine , clinical pharmacology , endocrinology , pharmacology , blood pressure
The serum levels of methyldopa and its principle metabolites were assessed in 22 hypertensive children, of whom 13 had impaired renal function. A significant correlation was found between the magnitude of the renal dysfunction and the serum levels of methyldopa, α‐methyldopa‐sulfate, α‐methyldopamine, and α‐methyldopamine‐sulfate. The patients were divided into 2 groups: those with normal (serum creatinine ≤ 1.0 mg/100 ml) and those with abnormal (serum creatinine > 1.0 mg/100 ml) renal function. The serum level of α‐methyldopa‐sulfate and not of methyldopa was elevated in those with renal dysfunction. The serum levels of α‐methyldopamine and, in particular, its 3‐0‐sulfate conjugate were markedly elevated in patients with renal disease. These data suggest that the enhanced sensitivity to methyldopa in patients with impaired renal function may be due in part to α‐methyldopamine. Clinical Pharmacology and Therapeutics (1980) 27, 37–43; doi: 10.1038/clpt.1980.6