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Analgesie effect of fluproquazone in postoperative patients
Author(s) -
Herrmann Ulrich,
Laube Walter,
Roth Fritz,
Schultheiss Hans R,
Berger Margrit,
Schürmann Paula,
Graffenried Beat,
Nüesch Erich
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.51
Subject(s) - medicine , anesthesia
In 4 double‐blind, randomized, stratified, parallel group studies, single oral doses of fluproquazone (75 to 200 mg), a new nonsteroidal anti‐inflammatory analgesic, were compared with aspirin (1,000 mg) and placebo in a total of 672 hospitalized patients with moderate or severe pain following episiotomy or other surgical interventions. A dose‐dependent effect of fluproquazone which was highly significantly superior to placebo and which resembled the effect of aspirin with respect to onset, degree, and duration was noted in all studies. Fluproquazone, 100 to 150 mg, was found to be approximately equiactive to 1,000 mg of aspirin and better tolerated. Clinical Pharmacology and Therapeutics (1980) 27, 379–385; doi: 10.1038/clpt.1980.51