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Metabolic effects of prazosin
Author(s) -
Barbieri Cristiano,
Caldara Roberto,
Ferrari Carlo,
Dal Bo Gabrio A,
Paracchi Alessandra,
Romussi Mario,
Curtarelli Guglielmo
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.41
Subject(s) - prazosin , phentolamine , endocrinology , medicine , prolactin , clinical pharmacology , adrenergic antagonist , hormone , insulin , endocrine system , gastrin , propranolol , chemistry , adrenergic , pharmacology , antagonist , receptor , secretion
The effects of oral administration of 2 mg prazosin on several metabolic and endocrine variables were evaluated in 12 patients with hypertension (6 with normal and 6 with abnormal glucose tolerance). Prazosin was followed by a rise in plasma glucose and serum free fatty acids (FFA) in both normal and diabetic subjects; there was a trend upward in serum insulin (IRI), but growth hormone (GH), prolactin (PRL), and gastrin did not change. Although these results are in general agreement with metabolic effects of other alpha adrenergic blockers already reported, the rise in plasma glucose is at variance with studies performed with phentolamine. Clinical Pharmacology and Therapeutics (1980) 27, 313–316; doi: 10.1038/clpt.1980.41