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Bioequivalence of subcutaneous calcium and sodium heparins
Author(s) -
Bender Frank,
Aronson Linda,
Hougie Cecil,
Moser Kenneth
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.35
Subject(s) - bioequivalence , partial thromboplastin time , calcium , clotting time , heparin , pharmacology , thrombin time , anticoagulant , chemistry , subcutaneous injection , medicine , coagulation , pharmacokinetics
The bioequivalence of subcutaneous porcine calcium and sodium heparins was studied in 48 normal male subjects randomly assigned to 1 of 4 study groups. Each subject received a single subcutaneous injection of 15,000 U of calcium heparin or 1 of 3 sodium heparins. Serial coagulation studies (Lee‐White clotting time, activated partial thromboplastin time, thrombin calcium clotting time, and heparin level) were performed over 10 hr. There were no significant differences in anticoagulant effect between groups. Clinical Pharmacology and Therapeutics (1980) 27 , 224–229; doi: 10.1038/clpt.1980.35