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Age and morphine analgesia in cancer patients with postoperative pain
Author(s) -
Kaiko Robert F
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.241
Subject(s) - medicine , morphine , analgesic , pain relief , anesthesia , potency , clinical pharmacology , cancer pain , retrospective cohort study , age groups , cancer , surgery , pharmacology , biochemistry , chemistry , demography , sociology , in vitro
Our objective was to identify age‐related differences in analgesia after 8 and 16 mg morphine intramuscularly. Retrospective analyses of controlled relative analgesic potency assays in 947 postoperative cancer patients revealed differences among age groups (18 to 29, 30 to 49, 50 to 69, and 70 to 89 yr) in total pain relief and duration of relief with little differences in peak relief. Weight and initial pain intensity were in the same range among age and dose groups. Aging was associated with enhanced analgesia. The difference in total relief between the extremes of adult age was approximately twice that with twice the dose. While in 50% of the oldest group relief was no longer obtained at 5 hr, in 50% of the youngest group relief was no longer obtained at 3 hr. These observations suggest that age is a factor in morphine analgesia. Clinical Pharmacology and Therapeutics (1980) 28 , 823–826; doi: 10.1038/clpt.1980.241