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Effects of danazol and lynestrenol on serum lipoproteins in endometriosis
Author(s) -
Mälkönen Marjatta,
Manninen Vesa,
Hirvonen Erkki
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.209
Subject(s) - lynestrenol , danazol , endometriosis , medicine , cholesterol , endocrinology , physiology , research methodology , population , family planning , environmental health
The treatment of endometriosis with danazol or lynestrenol decreased cholesterol content of plasma high‐density lipoproteins by 50% and 32%. There were simultaneous increases in low‐density lipoprotein cholesterol content of 51% and 19%. We suggest that changes induced by lynestrenol are due to progestational activity, while in the case of danazol both antigonadotropic and androgenic activities are involved. Clinical Pharmacology and Therapeutics (1980) 28, 602–604; doi: 10.1038/clpt.1980.209