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Clonidine‐chlorthalidone combination once and twice daily in essential hypertension
Author(s) -
Noveck Robert J,
Gilbert McMahon F,
Jain Adesh K,
Ryan Jerome R
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.206
Subject(s) - chlorthalidone , clonidine , bedtime , clinical pharmacology , medicine , blood pressure , essential hypertension , anesthesia , pharmacology
The antihypertensive effects of a clonidine‐chlorthalidone combination (Combipres) as a single daily dose at bedtime and the same amount in twice‐daily doses were compared in an open‐label, crossover study in 14 patients. An analysis of the blood pressure and pulse data in nine patients who completed the study revealed no statistically significant differences between the two regimens, and no difference in the incidence of side effects was noted. Clinical Pharmacology and Therapeutics (1980) 28, 581–586; doi: 10.1038/clpt.1980.206