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One and three doses of propranolol a day in hypertension
Author(s) -
Brink G,
Boer P,
Asten P,
Mees E J Dorhout,
Geyskes G G
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.2
Subject(s) - propranolol , chlorthalidone , clinical pharmacology , plasma renin activity , essential hypertension , medicine , pharmacology , plasma concentration , heart rate , anesthesia , blood pressure , diuretic , renin–angiotensin system
In 26 patients with essential hypertension who were on continuous chlorthalidone therapy, 1 and 3 daily doses of propranolol were compared in a crossover study. Plasma propranolol levels and heart rates had larger daily fluctuations on single‐dose therapy than on 3 times daily; plasma renin activity was more constant. There was no significant difference in blood pressures. Once‐daily propranolol dosage was well tolerated and possibly gave less rise to the troublesome side effect of vivid dreaming. Clinical Pharmacology and Therapeutics (1980) 27, 9–15; doi: 10.1038/clpt.1980.2