Premium
Interaction between diflunisal and warfarin
Author(s) -
Serlin Matthew J,
Mossman Stephen,
Sibeon Raymond G,
Tempero Kenneth F,
Breckenridge Alasdair M
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.193
Subject(s) - diflunisal , warfarin , chemistry , anticoagulant , prothrombin time , pharmacology , medicine , atrial fibrillation
The effect of diflunisal on steady‐state warfarin dynamics and kinetics was studied in five healthy men taking daily subtherapeutic doses of warfarin. Diflunisal 500 mg twice daily for 2 wk increased the percentage unbound warfarin from 1.02% to 1.34% and lowered total warfarin from 741 to 533 ng/ml, but did not alter the anticoagulant response (prothrombin complex activity, PCA). When diflunisal was discontinued but warfarin continued, there was a loss of anticoagulant effect and a difference in the rates at which percentage unbound warfarin and total warfarin concentration returned to prediflunisal levels. There was a correlation between plasma diflunisal and percentage unbound warfarin. Diflunisal reduced both the maximum plasma protein‐binding capacity for warfarin and the apparent association constant. Clinical Pharmacology and Therapeutics (1980) 28, 493–498; doi: 10.1038/clpt.1980.193