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Long‐term effects of captopril in hypertension
Author(s) -
Maruyama Anna,
Ogihara Toshio,
Naka Toru,
Mikami Hiroshi,
Hata Takeshi,
Nakamaru Mitsuaki,
Iwanaga Keiichi,
Kumahara Yuichi
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.168
Subject(s) - captopril , plasma renin activity , aldosterone , blood pressure , medicine , endocrinology , mean blood pressure , renin–angiotensin system , urinary system , angiotensin ii , essential hypertension , chemistry , heart rate
Captopril was given for treatment of hypertension alone or in combination with diuretics to 32 patients for 1‐ to 4‐mo periods. The decrement of mean blood pressure after 1 and 2 mo correlated with pretreatment plasma renin activity (PRA) and the response of blood pressure to infusion of an angiotensin II antagonist. These correlations were no longer apparent after 4 mo of treatment. When subjects with a decrement of mean blood pressure that exceeded 13 mm Hg were compared with nonresponders, responders not only had higher control PRA and higher PRA at 1 mo of treatment, but also had decreased plasma aldosterone levels, decreased urinary aldosterone excretion, and increased serum postassium levels that persisted over the 4 mo of observation. The reduction of plasma aldosterone correlated with the fall of mean blood pressure. Urinary kallikrein, catecholamines, electrolytes, and endogenous creatinine clearance did not change in response to treatment. These findings indicate that the antihypertensive activity of captopril on long‐term administration probably depends in part on the blockade of angiotensin II, but other mechanisms cannot be excluded. Clinical Pharmacology and Therapeutics (1980) 28, 316–323; doi: 10.1038/clpt.1980.168