Premium
Furosemide in patients with heart failure: Shift in dose‐response curves
Author(s) -
Brater D Craig,
Chennavasin Polavat,
Seiwell Ruth
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.148
Subject(s) - furosemide , heart failure , diuretic , medicine , clinical pharmacology , urine , excretion , pharmacology , urology , endocrinology , chemistry
We studied 10 patients with congestive heart failure to assess the dynamics of their response to 40 mg of furosemide. Patients excreted less sodium than normal controls: 142 ± 36 and 245 ± 16 mEq/4 hr (p < 0.05). Patients delivered the same amount of furosemide into the urine—14.9 ± 2.0 and 18.7 ± 2.1 mg/4 hr (p < 0.20)—but the time course of delivery differed. Normal subjects had a sigmoid‐shaped curve when furosemide excretion rate was related to response. All patients but one had shifts in this curve and for a number of patients the configuration differed substantially from a sigmoid curve. Clinical Pharmacology and Therapeutics (1980) 28, 182–186; doi: 10.1038/clpt.1980.148