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Chloramphenicol sodium succinate kinetics in critically ill patients
Author(s) -
Slaughter Richard L,
Pieper John A,
Cerra Frank B,
Brodsky Barbara,
Koup Jeffery R
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.133
Subject(s) - urine , chloramphenicol , renal function , critically ill , creatinine , pharmacology , medicine , chemistry , sodium , pharmacokinetics , urology , kinetics , excretion , endocrinology , antibiotics , biochemistry , physics , organic chemistry , quantum mechanics
Chloramphenicol sodium succinate (SCAP) kinetics were studied in 10 critically ill patients. High‐performance liquid chromatography was used to assay SCAP and chloramphenicol (CAP) in serum and urine. Total body (Cl TB ), metabolic (Cl M ), and renal (Cl R ) clearances of SCAP were variable. Correlations were found between creatinine clearance (Cl cr ) and Cl TB , Cl M , and Cl R of SCAP (r = 0.92, p < 0.001; r = 0.84, p < 0.005; and r = 0.84, p < 0.005). Recovery of SCAP in the urine also demonstrated large interpatient variability. Between 6.5% and 43.5% of the SCAP dose was recovered in the urine of 6 patients. This variability could not be explained by incomplete urine collection or by differences in renal function. Renal excretion of SCAP was shown to influence CAP serum levels. CAP Cl TB was diminished, but no relationship was found between routine liver function studies and CAP Cl TB . Therefore we caution the use of such relationships in using CAP in critically ill patients. Clinical Pharmacology and Therapeutics (1980) 28, 69–77; doi: 10.1038/clpt.1980.133