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Fenfluramine potentiation of antihypertensive effects of thiazides
Author(s) -
Raymond Lake C,
Ziegler Michael G,
Coleman Michael D,
Kopin Irwin J
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.125
Subject(s) - hydrochlorothiazide , thiazide , fenfluramine , diuretic , medicine , anorectic , clinical pharmacology , blood pressure , chlorothiazide , endocrinology , norepinephrine , essential hypertension , pharmacology , body weight , dopamine , serotonin , receptor
Hydrochlorothiazide, a drug which is often initially prescribed for mild to moderate hypertension, failed to lower blood pressures in 9 of 43 patients but concomitantly elevated plasma norepinephrine (NE) levels in all patients with hypertension. 20 The 9 obese hydrochlorothiazide‐resistant patients were then given fenfluramine, an anorectic, in addition to the thiazide. They were reevaluated after 2 and 5 wk, at which times there were reductions in blood pressures and marked reductions in the plasma NE levels which had been elevated by the hydrochlorothiazide. Since iatrogenic sympathetic activation seems undesirable in treating hypertension, fenfluramine may be useful in obese thiazide‐resistant hypertensive patients when used in combination with a thiazide diuretic. Clinical Pharmacology and Therapeutics (1980) 28, 22–27; doi: 10.1038/clpt.1980.125