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Age and beta adrenoceptor–mediated function
Author(s) -
Dillon Neil,
Chung Sydney,
Kelly John,
O'Malley Kevin
Publication year - 1980
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1038/clpt.1980.108
Subject(s) - beta (programming language) , medicine , beta adrenoceptor , endocrinology , cyclic adenosine monophosphate , adrenergic receptor , adenosine , cyclic gmp , heart rate , clinical pharmacology , pharmacology , receptor , nitric oxide , computer science , blood pressure , programming language
Beta adrenoceptor–mediated responsiveness to isoproterenol was compared in young and old subjects using the production of cyclic adenosine monophosphate (cyclic AMP) by lymphocytes as an index. The mean log dose‐response curve for the elderly group was displaced to the right and the mean maximum response was less than that for the young subjects. The results corroborate evidence of a decreased response to isoproterenol‐induced increases in heart rate in the elderly and raise the possibility of a generalized decrease in beta adrenoceptor–mediated functions in old age. Clinical Pharmacology and Therapeutics (1980) 27 , 769–772; doi: 10.1038/clpt.1980.108