Open AccessCalcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer
Author(s) -
Min Zhu,
Hongyi Wang,
Jiantao Cui,
Wenmei Li,
Gary An,
Yuanming Pan,
Qingying Zhang,
Rui Xing,
Youyong Lü
Publication year - 2017
Publication title -
cell death and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.482
H-Index - 111
ISSN - 2041-4889
DOI - 10.1038/cddis.2017.297
Subject(s) - calcium binding protein , calcium , metastasis , cancer , cancer research , microbiology and biotechnology , chemistry , cancer cell , biology , genetics , organic chemistry
S100A14 is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors. In this study, we characterized the regulation of S100A14 expression between biological signatures and clinical pathological features in gastric cancer (GC). Our data demonstrated that S100A14 induced the differentiation of GC by upregulating the expression of E-cadherin and PGII. Moreover, S100A14 expression negatively correlated with cell migration and invasion in in vitro and in vivo experimental models. Interestingly, S100A14 blocked the store-operated Ca 2+ influx by suppressing Orai1 and STIM1 expression, leading to FAK expression activation, focal adhesion assembly and MMP downregulation. Taken together, our results indicate that S100A14 may have a role in the induction of differentiation and inhibition of cell metastasis in GC.