Open AccessRegulatory non-coding RNA: new instruments in the orchestration of cell death
Author(s) -
Yue Su,
Haijiang Wu,
Alexander Pavlosky,
Lina Zou,
Xia Deng,
ZhuXu Zhang,
Anthony M. Jevnikar
Publication year - 2016
Publication title -
cell death and disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.482
H-Index - 111
ISSN - 2041-4889
DOI - 10.1038/cddis.2016.210
Subject(s) - necroptosis , biology , microrna , non coding rna , rna , programmed cell death , computational biology , microbiology and biotechnology , rna interference , gene expression , gene , regulation of gene expression , long non coding rna , transcription (linguistics) , genetics , apoptosis , linguistics , philosophy
Non-coding RNA (ncRNA) comprises a substantial portion of primary transcripts that are generated by genomic transcription, but are not translated into protein. The possible functions of these once considered ‘junk' molecules have incited considerable interest and new insights have emerged. The two major members of ncRNAs, namely micro RNA (miRNA) and long non-coding RNA (lncRNA), have important regulatory roles in gene expression and many important physiological processes, which has recently been extended to programmed cell death. The previous paradigm of programmed cell death only by apoptosis has recently expanded to include modalities of regulated necrosis (RN), and particularly necroptosis. However, most research efforts in this field have been on protein regulators, leaving the role of ncRNAs largely unexplored. In this review, we discuss important findings concerning miRNAs and lncRNAs that modulate apoptosis and RN pathways, as well as the miRNA–lncRNA interactions that affect cell death regulation.