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Finding better therapeutic targets for patients with asthma: adenosine receptors?
Author(s) -
Polosa R
Publication year - 2008
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/bjp.2008.364
Subject(s) - adenosine , adenosine receptor , asthma , medicine , receptor , pharmacology , drug development , clinical trial , perspective (graphical) , neuroscience , drug , bioinformatics , immunology , biology , agonist , computer science , artificial intelligence
Recent observations suggest a potential pathophysiological function for adenosine signalling in chronic inflammation of the airways, and development of new selective agonists or antagonists for adenosine receptor subtypes has recently lead to a number of clinical trials of such agents in asthma. The review by Wilson in this issue of the BJP provides a critical perspective on adenosine receptors as rational targets for drug development for anti‐asthma drugs with a focus on their efficacy and safety. Important conclusions can be drawn about the function of adenosine receptors in human asthma and approaches to these important targets with novel therapeutic agents. British Journal of Pharmacology (2008) 155 , 441–443; doi: fn1