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Viral vectors: from virology to transgene expression
Author(s) -
Bouard D,
AlazardDany N,
Cosset FL
Publication year - 2009
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/bjp.2008.349
Subject(s) - virology , transgene , genetic enhancement , vector (molecular biology) , viral vector , herpes simplex virus , biology , vectors in gene therapy , virus , gene , computational biology , genetics , recombinant dna
In the late 1970s, it was predicted that gene therapy would be applied to humans within a decade. However, despite some success, gene therapy has still not become a routine practise in medicine. In this review, we will examine the problems, both experimental and clinical, associated with the use of viral material for transgenic insertion. We shall also discuss the development of viral vectors involving the most important vector types derived from retroviruses, adenoviruses, herpes simplex viruses and adeno-associated viruses.