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Arachidonic acid and ion channels: an update
Author(s) -
Meves H
Publication year - 2008
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/bjp.2008.216
Subject(s) - transient receptor potential channel , arachidonic acid , ion channel , chemistry , polyunsaturated fatty acid , stretch activated ion channel , voltage dependent calcium channel , receptor , pharmacology , calcium , biochemistry , fatty acid , medicine , voltage gated ion channel , enzyme , organic chemistry
Arachidonic acid (AA), a polyunsaturated fatty acid with four double bonds, has multiple actions on living cells. Many of these effects are mediated by an action of AA or its metabolites on ion channels. During the last 10 years, new types of ion channels, transient receptor potential (TRP) channels, store‐operated calcium entry (SOCE) channels and non‐SOCE channels have been studied. This review summarizes our current knowledge about the effects of AA on TRP and non‐SOCE channels as well as classical ion channels. It aims to distinguish between effects of AA itself and effects of AA metabolites. Lipid mediators are of clinical interest because some of them (for example, leukotrienes) play a role in various diseases, others (such as prostaglandins) are targets for pharmacological therapeutic intervention. British Journal of Pharmacology (2008) 155 , 4–16; doi: 10.1038/bjp.2008.216 ; published online 16 June 2008