Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease | Zendy

Biljana Jovov | Zendy; Jianwen Que | Zendy; Nelia A. Tobey | Zendy; Zorka Djukic | Zendy; Brigid L.M. Hogan | Zendy; Roy C. Orlando | Zendy

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Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease

Author(s) -

Biljana Jovov,

Jianwen Que,

Nelia A. Tobey,

Zorka Djukic,

Brigid L.M. Hogan,

Roy C. Orlando

Publication year - 2011

Publication title -

the american journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.907

H-Index - 252

eISSN - 1572-0241

pISSN - 0002-9270

DOI - 10.1038/ajg.2011.102

Subject(s) - gerd , western blot , pathogenesis , medicine , esophagus , reflux , immunostaining , pathology , endocrinology , gastroenterology , immunohistochemistry , biology , disease , biochemistry , gene

An early event in the pathogenesis of gastroesophageal reflux disease (GERD) is an acid-induced increase in junctional (paracellular) permeability in esophageal epithelium (EE). The molecular events that account for this change are unknown. E-cadherin is a junctional protein important in barrier function in EE. Therefore, defects in barrier function in EE were sought in GERD as well as whether their presence correlated with abnormalities in e-cadherin.

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