
An older subjective age is related to accelerated epigenetic aging.
Author(s) -
Yannick Stéphan,
Angelina R. Sutin,
Martina Luchetti,
Antonio Terracciano
Publication year - 2021
Publication title -
psychology and aging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.468
H-Index - 151
eISSN - 1939-1498
pISSN - 0882-7974
DOI - 10.1037/pag0000607
Subject(s) - psychology , cognitive aging , epigenetics , successful aging , senescence , developmental psychology , healthy aging , accelerated aging , gerontology , cognition , cognitive psychology , clinical psychology , neuroscience , medicine , genetics , reliability engineering , biology , gene , engineering
The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge. Regression analysis revealed that an older subjective age was associated with accelerated epigenetic aging; mediation analysis revealed that self-rated health and CRP accounted for this association. The findings indicate that individuals who feel older than their chronological age are biologically older, in part because of their perceived health and inflammatory profiles. (PsycInfo Database Record (c) 2021 APA, all rights reserved).