Open AccessMemory in multiple sclerosis: A reappraisal using the item specific deficit approach.
Author(s) -
Michael R. Basso,
Douglas M. Whiteside,
Dennis R. Combs,
Steven Paul Woods,
Jordan Hoffmeister,
Ryan Mulligan,
Peter A. Arnett,
Eva C. Alden,
W. Oliver Tobin
Publication year - 2021
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 130
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000712
Subject(s) - multiple sclerosis , neuropsychology , psychology , cognition , cognitive psychology , extant taxon , verbal memory , verbal learning , developmental psychology , audiology , neuroscience , medicine , psychiatry , evolutionary biology , biology
As many as 65% of people with multiple sclerosis (MS) have clinically significant memory impairment, but the nature of this deficit is controversial. Some investigations suggest that an inability to retrieve newly learned information from memory is prominent, whereas others imply that compromised acquisition accounts for impairment. Prior research has not simultaneously evaluated acquisition and retrieval processes in MS, and fewer have attempted to account for initial acquisition when studying retrieval. The Item Specific Deficit Approach (ISDA) offers a method of quantifying acquisition, retrieval, and retention processes, with the latter two mechanisms being adjusted for initial acquisition. To simultaneously quantify acquisition and retrieval abilities, the ISDA was applied to list learning performance in two independent samples of people with MS and corresponding healthy comparison groups.