Open AccessFunctional reserve: The residual variance in instrumental activities of daily living not explained by brain structure, cognition, and demographics.
Author(s) -
A. Zarina Kraal,
Lauren Massimo,
Evan Fletcher,
Carmen I. Carrión,
Luis D. Medina,
Dan M Mungas,
Brandon E. Gavett,
Sarah Farias
Publication year - 2021
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000705
Subject(s) - cognitive reserve , psychology , dementia , cognition , activities of daily living , apathy , developmental psychology , clinical psychology , gerontology , disease , psychiatry , medicine , cognitive impairment
Cognitive reserve is a concept that explains individual differences in resilience to brain pathology and susceptibility to poor late-life cognitive outcomes. We evaluate the analogous concept of "Functional Reserve," defined as the difference between observed functional abilities and those predicted by brain structure, cognitive performance, and demographics. This study aims to validate the construct of functional reserve by testing its utility in predicting clinical outcomes and exploring its predictors.