Open AccessNeural correlates of daily function: A pilot study of the white matter retrogenesis hypothesis and three separate performance-based functional assessments.
Author(s) -
Luis D. Medina,
Kate S. Heffernan,
Samantha K. Holden,
Abigail Simpson,
Brianne M. Bettcher
Publication year - 2021
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 130
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000649
Subject(s) - psychology , fractional anisotropy , white matter , cognition , audiology , neural correlates of consciousness , diffusion mri , developmental psychology , medicine , magnetic resonance imaging , neuroscience , radiology
Increasing evidence points to mild alterations in everyday functioning early in the course of Alzheimer's disease and related dementias (ADRD), despite prior research suggesting functional declines occur primarily in later stages. However, daily function assessment is typically accomplished with subjective self- or informant-report, which can be prone to error due to various factors. Performance-based functional assessments (PBFAs) allow for objective evaluation of daily function abilities, but little is known on their sensitivity to the earliest ADRD-related brain alterations. We aimed to determine the neural correlates of three different PBFAs in a pilot study.