Open AccessDepressive symptoms precede cognitive impairment in de novo Parkinson’s disease patients: Analysis of the PPMI cohort.
Author(s) -
Jacob D. Jones,
N Kurniadi,
Taylor Kuhn,
Sarah M. Szymkowicz,
Joseph Bunch,
Elizabeth Rahmani
Publication year - 2019
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000583
Subject(s) - apathy , neurocognitive , psychology , anxiety , mood , cognition , verbal learning , clinical psychology , depression (economics) , verbal memory , psychiatry , economics , macroeconomics
Nonmotor symptoms, including depression, anxiety, apathy, and cognitive dysfunction, are common in Parkinson's disease (PD). Although a link between mood symptoms and cognitive impairment in PD has been theorized vis-à-vis striatal dopamine depletion, studies have been inconsistent regarding the relationship between mood symptoms and cognitive function. Inconsistencies may reflect the cross-sectional nature of previous studies. The current study examined the bidirectional longitudinal relationship between mood and cognition.