Open AccessBrain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review.
Author(s) -
Edith V. Sullivan,
Adolf Pfefferbaum
Publication year - 2019
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 130
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000557
Subject(s) - sobriety , neuroimaging , alcohol use disorder , neuropsychology , psycinfo , psychology , dementia , alcohol dependence , brain structure and function , cognition , clinical psychology , medicine , psychiatry , alcohol , medline , disease , biochemistry , chemistry , political science , law
Alcohol use disorder (AUD) is a complex, dynamic condition that waxes and wanes with unhealthy drinking episodes and varies in drinking patterns and effects on brain structure and function with age. Its excessive use renders chronically heavy drinkers vulnerable to direct alcohol toxicity and a variety of comorbidities attributable to nonalcohol drug misuse, viral infections, and accelerated or premature aging. AUD affects widespread brain systems, commonly, frontolimbic, frontostriatal, and frontocerebellar networks.