Open AccessEffects of APOE on cognitive aging in community-dwelling older adults.
Author(s) -
Emilie T. Reas,
Gail A. Laughlin,
Jaclyn Bergstrom,
Donna KritzSilverstein,
Elizabeth BarrettConnor,
Linda K. McEvoy
Publication year - 2019
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000501
Subject(s) - cognitive decline , cognition , verbal fluency test , psychology , gerontology , apolipoprotein e , effects of sleep deprivation on cognitive performance , episodic memory , dementia , medicine , disease , psychiatry , neuropsychology
The apolipoprotein E (APOE) gene is an established risk factor for sporadic Alzheimer's disease, with elevated risk for ε4-carriers and reduced risk for ε2-carriers. However, it is unclear whether APOE modifies risk for cognitive decline in normal aging. The objective of this study was to determine whether ε2 and ε4 are associated with rates of normal cognitive aging, and whether associations of ε4 with cognitive decline are modified by sex, education or health behaviors (exercise, alcohol consumption, smoking).