Open AccessLongitudinal intra-individual variability in neuropsychological performance relates to white matter changes in HIV.
Author(s) -
Jacob D. Jones,
Taylor Kuhn,
Zanjbeel Mahmood,
Elyse J. Singer,
Charles H. Hinkin,
April D. Thames
Publication year - 2018
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 130
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000390
Subject(s) - neuropsychology , neurocognitive , white matter , fractional anisotropy , medicine , neuroimaging , cognition , human immunodeficiency virus (hiv) , psychology , clinical psychology , psychiatry , magnetic resonance imaging , immunology , radiology
Recent studies suggest that intraindividual variability (IIV) of neuropsychological performance may be sensitive to HIV-associated neurologic compromise. IIV may be particularly dependent upon the integrity of frontal-subcortical systems, and therefore may be a meaningful phenotype in HIV. We examined the relationship between change in IIV and white matter integrity among HIV seropositive (HIV+) and HIV seronegative (HIV-) individuals.