Open AccessGenetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study.
Author(s) -
Sherilyn Thibeau,
G. Peggy McFall,
Sandra A. Wiebe,
Kaarin J. Anstey,
Roger A. Dixon
Publication year - 2016
Publication title -
neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 130
eISSN - 1931-1559
pISSN - 0894-4105
DOI - 10.1037/neu0000217
Subject(s) - psychology , longitudinal study , confirmatory factor analysis , rs6265 , neurotrophic factors , gerontology , developmental psychology , brain derived neurotrophic factor , medicine , structural equation modeling , statistics , mathematics , pathology , receptor
Everyday physical activity (EPA) is an important modifiable contributor to age-related variability in executive functioning (EF). However, its role may be moderated by nonmodifiable genetic factors. We tested independent and interactive effects of brain-derived neurotrophic factor (BDNF rs6265) and insulin degrading enzyme (IDE rs6583817) on EF and EPA-EF relationships.