Discrimination of computer-graphic stimuli by mice: A method for the behavioral characterization of transgenic and gene-knockout models. | Zendy

Timothy J. Bussey | Zendy; Lisa M. Saksida | Zendy; Lawrence A. Rothblat | Zendy

Open Access

Discrimination of computer-graphic stimuli by mice: A method for the behavioral characterization of transgenic and gene-knockout models.

Author(s) -

Timothy J. Bussey,

Lisa M. Saksida,

Lawrence A. Rothblat

Publication year - 2001

Publication title -

behavioral neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.918

H-Index - 140

eISSN - 1939-0084

pISSN - 0735-7044

DOI - 10.1037/0735-7044.115.4.957

Subject(s) - knockout mouse , genetically modified mouse , gene knockout , psychology , behavioral analysis , neuroscience , transgene , set (abstract data type) , wheel running , biology , gene , developmental psychology , computer science , genetics , endocrinology , programming language

An automated method is described for the behavioral testing of mice in an apparatus that allows computer-graphic stimulus material to be presented. Mice responded to these stimuli by making a nose-poke toward a computer monitor that was equipped with a touchscreen attachment for detecting responses. It was found that C57BL/6 mice were able to solve single-pair visual discriminations as well as 3-pair concurrent visual discriminations. The finding that mice are capable of complex visual discriminations introduces the possibility of testing mice on nonspatial tasks that are similar to those used with rats, monkeys, and humans. Furthermore, the method seems particularly well suited to the comprehensive behavioral assessment of transgenic and gene-knockout models.

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