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Drug effects on salivary glands: dry mouth
Author(s) -
Scully CBE C
Publication year - 2003
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1034/j.1601-0825.2003.03967.x
Subject(s) - dry mouth , medicine , anticholinergic , saliva , drug , pharmacology
Objective: To identify drugs associated with the complaint of dry mouth. Materials and Methods: MEDLINE was searched for papers 1980–2002 using keywords, oral, mouth, salivary, drugs, dry mouth and xerostomia, and relevant secondary references were hand‐searched. Results: Evidence was forthcoming for a number of xerogenic drugs, especially antimuscarinic agents, some sympathomimetic agents, and agents affecting serotonin and noradrenaline uptake, as well as a miscellany of other drugs such as appetite suppressants, protease inhibitors and cytokines. Conclusion: Dry mouth has a variety of possible causes but drugs – especially those with anticholinergic activity against the M3 muscarinic receptor – are the most common cause of reduced salivation.