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Recurrent herpes labialis: efficacy of topical therapy with penciclovir compared with acyclovir (aciclovir)
Author(s) -
Femiano F,
Gombos F,
Scully C
Publication year - 2001
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1034/j.1601-0825.2001.70107.x
Subject(s) - penciclovir , aciclovir , medicine , dermatology , lesion , population , surgery , virology , viral disease , herpesviridae , virus , herpes simplex virus , environmental health
This study compares the effects of topical acyclovir and penciclovir in the treatment of recurrent herpes labialis. The study patients were a population of 40 patients with in excess of five recurrences annually, and were separated into four homogeneous groups each of 10 subjects. The antiviral creams were used to achieve total lesional cover, every 2 h during waking hours. The effects on the time to lesion crusting and to resolution of pain, were assessed. The results not only confirmed that aciclovir is ineffective, but confirmed that penciclovir is effective, and that penciclovir is superior to aciclovir.