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Role of Nitric Oxide Synthase (NOS) During Ex Vivo Warm Kidney Perfusion Prior to Renal Transplantation
Author(s) -
Reid Kaye M.,
Geller David A.
Publication year - 2003
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1034/j.1600-6143.2003.00143.x
Subject(s) - ex vivo , medicine , transplantation , economic shortage , perfusion , kidney , kidney transplantation , machine perfusion , renal function , in vivo , urology , surgery , cardiology , biology , microbiology and biotechnology , liver transplantation , linguistics , philosophy , government (linguistics)
Due to the shortage of available organ donors and the growing renal transplantation waiting list, most transplant centers are utilizing kidneys from an expanded donor pool that consists of older kidneys and those with longer cold ischemia times. In addition, some centers are re-addressing the issue of pumping kidneys (ex vivo hypothermic perfusion) to optimize marginal grafts as a technique to expand the donor pool. In the accompanying report by Brasile et al. (1), the investigators describe excellent function following long-term (48 h) ex vivo warm perfusion of canine autotransplanted kidneys.