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Regulatory T Cells in the Control of Transplantation Tolerance and Autoimmunity
Author(s) -
Jiang Shuiping,
Lechler Robert I.
Publication year - 2003
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1034/j.1600-6143.2003.00124.x
Subject(s) - medicine , autoimmunity , transplantation , immunology , intensive care medicine , immune system
A role for immunoregulatory T cells in the maintenance of self‐tolerance and in transplantation tolerance has long been suggested, but the identification of such cells has not been achieved until recently. With the characterisation of spontaneously occurring CD4 + CD25 + and NK1.1 + T subpopulations of T cells as regulatory cells in rodents and in humans, together with several in vitro generated regulatory T‐cell populations, it seems possible that ‘customised’ regulatory cells possessing antidonor specificity may become therapeutic tools in clinical transplantation tolerance.