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Kidney‐Pancreas Transplantation in a Long‐Term Non‐Progressor HIV‐Infected Recipient
Author(s) -
Toso Christian,
Berney Thierry,
Oberholzer José,
Chave JeanPhilippe,
Martin PierreYves,
Zeender Eve,
Bosco Domenico,
Morel Philippe
Publication year - 2003
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1034/j.1600-6143.2003.00119.x
Subject(s) - contraindication , medicine , transplantation , pancreas transplantation , kidney transplantation , immunosuppression , organ transplantation , human immunodeficiency virus (hiv) , immunology , intensive care medicine , virology , pathology , alternative medicine
With the introduction of highly active antiretroviral therapy (HAART), HIV infection has become a chronic disease with more frequent end‐stage organ failures. As a result, the question of transplantation in HIV patients is raised more often. Although still subject to controversies, HIV infection is no longer an absolute contraindication to solid organ transplantation. We report a case of combined kidney‐pancreas transplantation in a HIV recipient. HIV has remained stable without any antiviral therapy for up to 2 years after transplantation and has reached criteria for inclusion in the long‐term nonprogressor (LTNP) group. Grafted organs demonstrated good function without rejection. This case emphasizes the need to consider LTNP HIV patients as a specific subgroup, when discussing solid organ transplantation. HAART is not required, thus sparing drug interactions and their unique immunological features, such as CCR5 mutation, might prevent rejection. This subgroup of HIV patients should be offered less restricted access to transplantation.