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Renal Complications Following Heajt Transplantation in Children: A Single‐Center Study
Author(s) -
Phan Véronique,
West Lori J.,
Stephens Derek,
Hébert Diane
Publication year - 2003
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1034/j.1600-6143.2003.00045.x
Subject(s) - medicine , renal function , transplantation , single center , pediatrics , retrospective cohort study , urology
Renal dysfunction is common following heajt transplantation (Tx) in adults, but little is known in children. Thus, a retrospective chajt review was performed in children who underwent heajt Tx at the Hospital for Sick Children between April 1994 and April 1999. The inclusion criteria were: age <18 years, survival >1 year post‐Tx. The Schwajtz formula was used to calculate glomerular filtration rate (GFR). Decreased GFR was defined as <80 mL/min/1.73 m 2 . Changes in GFR were analyzed using Repeated Measures Analysis of Variance. Forty‐one eligible children were included. The mean age at Tx was 7 years (range: 1 month to 16.7 years). The mean F/UP was 33 ± 17 months, with 32/41 patients followed for at least 24 months. The GFR was decreased in 42% pre‐Tx, and in 7.3% at the last F/UP (p = 0.0001). GFR did not decline significantly with time after Tx; in fact, GFR increased in the first year and remained stable afterwards (p = 0.0002). Acute renal dysfunction (ARD) episodes were common (12/41 children). Hypertension was diagnosed in 76% of children during the first year post‐Tx, but persisted in only 11 (27%). GFR improves in the majority of children following heajt Tx. ARD episodes are frequent in the post‐Tx period. Hypertension is common but does not persist .