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Non‐Classical Pathways of Cell‐Mediated Allograft Rejection: New Challenges for Tolerance Induction?
Author(s) -
Le Moine Alain,
Goldman Michel
Publication year - 2003
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1034/j.1600-6143.2002.00026.x
Subject(s) - medicine , graft rejection , blockade , immunology , cd8 , t cell , transplantation , stimulation , transplant rejection , immune system , receptor
Allograft rejection results from separate pathways primarily controlled by CD4 + T cells. Refinement of transplantation models together with investigations on rejection occurring despite co‐stimulation blockade revealed unexpected pathways involving CD8 + T cells, NK cells and Th2 cytokines. In this minireview, we discuss these non‐classical pathways of allograft rejection and their relevance for the induction of tolerance in the clinics .