Premium
Genetic Contribution of the Interleukin‐10 Promoter Polymorphism in Endometriosis Susceptibility
Author(s) -
KITAWAKI JO,
OBAYASHI HIROSHI,
OHTA MITSUHIRO,
KADO NORIKO,
ISHIHARA HIROAKI,
KOSHIBA HISATO,
KUSUKI IZUMI,
TSUKAMOTO KATSUMI,
HASEGAWA GOJI,
NAKAMURA NAOTO,
YOSHIKAWA TOSHIKAZU,
HONJO HIDEO
Publication year - 2002
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1034/j.1600-0897.2002.1o029.x
Subject(s) - endometriosis , genotype , biology , promoter , restriction fragment length polymorphism , allele , genetic predisposition , allele frequency , polymorphism (computer science) , polymerase chain reaction , gene , genetics , interleukin , microbiology and biotechnology , immunology , cytokine , medicine , gene expression
PROBLEM: Interleukin‐10 (IL‐10) is an important immunomodulatory cytokine. The aim of this study was to investigate whether polymorphisms of the IL‐10 gene promoter polymorphisms may be responsible in part for genetic susceptibility to endometriosis. METHODS OF STUDY: Polymorphisms at position −1082 and −592 in the IL‐10 promoter region were determined in 196 patients with endometriosis and 160 fertile healthy women by polymerase chain reaction (PCR)‐restriction fragment length polymorphism (RFLP). RESULTS: There were no statistically significant differences in the genotype and allele frequencies of IL‐10 promoter polymorphism between the endometriosis and control groups. However, when subgrouped according to clinical features, the frequencies of the −592*CC genotype and −592*C allele were significantly increased in patients with autoantibodies to carbonic anhydrase II (anti‐CA II ab) compared with controls. CONCLUSION: IL‐10 promoter polymorphisms were associated with the production of anti‐CA II ab in patients with endometriosis, suggesting a role in the genetic susceptibility for endometriosis.