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Evaluation of Serum CA 125 Concentration Before and During Hormonal Induced Cycles as Predictor of IVF/ET Outcome
Author(s) -
Vujisić Sanja,
Kupešić Sanja,
Mihaljević Daria,
Akšamija Alenka,
Kurjak Asim
Publication year - 2002
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1034/j.1600-0897.2002.01088.x
Subject(s) - follicular phase , in vitro fertilisation , embryo transfer , andrology , endometrium , medicine , gynecology , ovarian follicle , endocrinology , chemistry , pregnancy , biology , genetics
Vujisić S, Kupešić S, Mihaljević D, Akšamija A, Kurjak A. Evaluation of serum CA 125 concentration before and during hormonal induced cycles as predictor of IVF/ET outcome. AJRI 2002; 48:355–360 © Blackwell Munksgaard, 2002 PROBLEM: To evaluate the role of CA 125 in prediction of in vitro fertilization and embryo transfer (IVF/ET) outcome. METHOD OF STUDY: Serum CA 125 concentrations were evaluated in the spontaneous and stimulated cycles of 33 patients. CA 125 was measured using a microparticle enzyme immunoassay (MEIA) (Abbott, Diagnostics, USA). Follicular growth, endometrial thickness and subendometrial blood flow were evaluated by transvaginal color Doppler ultrasound. Statistical analysis was performed by Wilcoxon rank‐sum test and Friedman test. RESULTS: There was no statistically significant difference ( P > 0.05) of CA 125 values between spontaneous and stimulated cycles, and between pregnant and non‐pregnant patients. A CA 125 rise from the late proliferative to the early secretory phase ( P < 0.05) was obtained only in the stimulated cycles. There was no relationship between CA 125, follicle number, endometrial thickness and resistance index of the subendometrial vessels. CONCLUSION: CA 125 levels are not predictive of ovarian and endometrial response. Hormonal stimulation does not effect serum CA 125 concentration. There was no influence of CA 125 levels on IVF/ET outcome in stimulated cycles.