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High Serum Interleukin‐8 Levels in Afro‐Caribbean Women with Pre‐eclampsia. Relations with Tumor Necrosis Factor‐α, Duffy Negative Phenotype and Von Willebrand Factor
Author(s) -
VelzingAarts Francien V.,
Muskiet Frits A.J.,
Van Der Dijs Fey P.L.,
Duits Ashley J.
Publication year - 2002
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1034/j.1600-0897.2002.01087.x
Subject(s) - medicine , endocrinology , tumor necrosis factor alpha , von willebrand factor , interleukin 6 , phenotype , eclampsia , interleukin , immunology , biology , cytokine , pregnancy , platelet , gene , biochemistry , genetics
Velzing‐Aarts FV, van der Dijs FPL, Muskiet FAJ, Duits AJ. High serum interleukin‐8 levels in Afro‐Caribbean women with pre‐eclampsia. Relations with tumor necrosis factor‐α, Duffy negative phenotype and von Willebrand factor. AJRI 2002; 48:319–322 © Blackwell Munksgaard, 2002 PROBLEM: Pre‐eclampsia is characterized by neutrophil activation. Interleukin‐8 (IL‐8) is a strong neutrophil chemo‐attractant and activator. METHOD OF STUDY: We measured serum IL‐8 in 13 pre‐eclamptic Afro‐Caribbean women and 13 gestational age‐, race‐ and parity‐matched normotensive and non‐proteinuric controls. We also determined serum tumor necrosis factor‐α (TNF‐α), the phenotypes of the IL‐8 binding Duffy blood group antigen receptor and the von Willebrand factor (vWF) plasma levels. RESULTS: Serum IL‐8, TNF‐α, Duffy negative phenotype frequency and plasma vWF were higher in pre‐eclamptic women compared with controls. IL‐8 correlated positively with both TNF‐α and vWF in the entire study group. CONCLUSIONS: Higher IL‐8 levels in pre‐eclampsia may result from increased production (secondary to increased TNF‐α levels) and/or reduced clearance (related to a high frequency of Duffy negative phenotype).