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Antitrophoblast cell‐mediated immunity and anticardiolipin autoantibodies in repeatedly aborting women
Author(s) -
Madar J.,
Sula K.,
Chaloupkova A.,
Peknicova J.,
Novakova D.
Publication year - 2002
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1034/j.1600-0897.2002.00005.x
Subject(s) - autoantibody , immunology , medicine , miscarriage , pregnancy , antibody , recurrent miscarriage , immunity , antiphospholipid syndrome , immune system , biology , genetics
This presentation is focused on immunopathological mechanisms involved in habitual miscarriage, namely on the anti‐trophoblast cell mediated immunity and circulating anti‐cardiolipin autoantibodies. PATIENTS: A group of habitually aborting women (three or more subsequent first‐trimester miscarriages, n = 216) was compared with two control groups – nulliparous women ( n = 74) and ‘fertile’ women ( n = 32) with at least one physiological pregnancy and no miscarriage in their personal history. METHODS: Cell‐mediated antitrophoblast immunity (AT‐CMI) was measured by the inhibition of migration of circulating leukocytes in the presence of antigen (choriocarcinoma cells JAR). Anticardiolipin autoantibodies (ACLA) of IgG and IgM types as well as serum levels of immunoglobulins (IgA, IgG, IgM) were determined using commercial diagnostic sets. RESULTS: AT‐CMI and ACLA‐IgG titres were significantly increased in habitually aborting women in comparison with both control groups. The elevation of AT‐CMI in fertile women as compared with nulliparae was not significant. Serum levels of total IgA, IgG and IgM immunoglobulins did not differ significantly. CONCLUSIONS: Our results indicate that the elevation of antitrophoblast immunity often accompa‐ nies habitual first‐trimester aborts. Anticardiolipin autoantibodies are also elevated in aborting women.