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Expansion of the Fraction of Th1 Cells in Women with Preeclampsia: Inverse Correlation between the Percentage of Th1 Cells and the Plasma Level of PAI‐2
Author(s) -
OHKUCHI AKIHIDE,
MINAKAMI HISANORI,
AOYA TOSHIO,
HAGA TORU,
KIMURA HIROKAZU,
SUZUKI MITSUAKI,
SATO IKUO
Publication year - 2001
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1034/j.1600-0897.2001.d01-10.x
Subject(s) - preeclampsia , gestation , endocrinology , medicine , peripheral blood mononuclear cell , andrology , plasminogen activator , pregnancy , chemistry , biology , in vitro , biochemistry , genetics
PROBLEM: The fractions of Th1 cells and Tc1 cells may be increased in preeclamptic women compared with healthy pregnant women.
METHOD OF STUDY: Eleven healthy non‐pregnant women, nine healthy pregnant women (34.1±3.1 weeks of gestation), and 10 women with preeclampsia (32.0±5.4 weeks) were studied. The fractions of Th1 cells, Th2 cells, Tc1 cells, and Tc2 cells in the peripheral blood mononuclear cells were determined using a three‐color flow cytometric technique. The concentrations of plasma plasminogen activator inhibitor‐2 (PAI‐2) were simultaneously determined.
RESULTS: The fraction of Th1 cells was significantly larger in women with preeclampsia (18.7±5.2%) than in normal pregnant women (11.0±5.7%), and it increased with a decrease in the PAI‐2 level ( r =−0.706, P =0.002), which was significantly lower in preeclamptic women (83.4±46.8 ng/mL) than in normal pregnant women (225.3±82.0 ng/mL). The fraction of Tc1 cells increased with increases in the fraction of Th1 cells ( r =0.657, P <0.001) and the ratio of Th1‐to‐Th2 cells ( r =0.535, P =0.002). The ratio of Tc1‐to‐Tc2 cells also increased with an increase in the ratio of Th1‐to‐Th2 cells ( r =0.394, P =0.031).
CONCLUSIONS: The fraction of Th1 cells appears to be expanded in women with preeclampsia compared with healthy pregnant women.